Abstract
In 2 patients with mycosis fungoides, a squamous cell carcinoma developed during therapy with psoralens plus long-wave UV radiation (PUVA). In both patients the carcinoma developed on areas not usually exposed to sunlight. Before receiving PUVA therapy 1 patient was treated with topically applied thiotepa and X-ray irradiation, while in the other patient PUVA was the only treatment received except for topical corticosteroids. The carcinomas developed after a total UVA dose of 2042 and 1296 J/cm2, respectively.