THE EFFECT OF URINARY GLUCOSE EXCRETION ON THE PLASMA GLUCOSE CLEARANCES AND PLASMA INSULIN RESPONSES TO INTRAVENOUS GLUCOSE LOADS IN UNANAESTHESIZED DOGS

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Abstract
The effect of urinary glucose excretion on the plasma glucose clearance and insulin response to varying sizes of glucose loads was studied in normal unanesthesized dogs. Glucose loads ranging from 0.15-1.25 g/kg b.w. [body weight] were infused i.v. in a standard time period of 30 s. Plasma glucose and plasma immunoreactive insulin (IRI) concentrations were determined for 1 h after infusion. All urine excreted during the 1 h was collected by a catheterization and bladder washout procedure. The urinary glucose excretion was expressed as the percent of the glucose load. The urinary glucose excretion varied directly with the size of the glucose load and ranged from minimal to 12%. Urinary losses play a considerable role proportionate to the degree of hyperglycemia above the renal threshold. Urinary loss of glucose must be recognized as an important factor influencing the plasma glucose clearance and hence the plasma IRI [immunoreactive insulin] response. A glucose load of 0.5 g/kg b.w. given in 30 s with the k-value calculated between 15-45 min would minimize the influence of urinary loss and provide more accurate plasma clearance values.

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