Passive calcium movements in dog red blood cells: anion effects

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Abstract
Ca influx in dog red blood cells was stimulated by replacing chloride in the medium with nitrate or thiocyanate. These anion effects were due to stimulation of a Na dependent Ca pathway, because Ca influx in the presence of nitrate or thiocyanate was inhibited by external Na, dependent on internal Na, inhibited by cell shrinkage and low pH, and inhibited by quinidine. All these characteristics had previously been shown to hold for Ca movements in the presence of chloride. Neither nitrate nor thiocyanate caused an irreversible change in Ca transport in the concentrations studied. Ca-stimulated Na efflux is stimulated when chloride is replaced by thiocyanate but not by nitrate. Several limiting features of the system are discussed, which preclude a conclusive interpretation of the data. The possibility is considered that the rates of Na dependent Ca transport in the presence of chloride, nitrate and thiocyanate are a function of the conductance of these anions.

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