Some actions of amantadine on peripheral tissues

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Abstract
Amantadine has been tested on several peripheral preparations. It depressed responses of the chick isolated oesophagus to nicotine and preganglionic parasympathetic nerve stimulation without depressing responses to acetylcholine. It did not affect the amplitude or duration of action potentials in toad sciatic nerve. It enhanced the effects of noradrenaline and dopamine while reducing the effect of tyramine on the coaxially stimulated guinea-pig ileum, isolated central artery of the rabbit ear and spontaneously beating guinea-pig isolated atria preparations. Amantadine enhanced the depressor effect of dopamine in the rabbit.