Failure of methapyrilene to induce tumors in hamsters or guinea pigs

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Abstract
In a small-scale experiment, 12 male and 12 female strain 2 guinea pigs were treated by gavage 2/wk for 78 wk with a 200 mg/kg body wt dose of methapyrilene hydrochloride dissolved in water, a total dose of .apprx. 30 g/kg body wt. By the end of the treatment more than half of the animals were still alive: survivors were killed at 132 wk. A group of 20 male Syrian golden hamsters was treated 2/wk by gavage with 15 mg methapyrilene hydrochloride for 58 wk, a total dose of .apprx. 15 g/kg body wt. Animals (13) survived an acute convulsant effect, and the last 4 were killed at week 61. There was no significant incidence of any tumor that could be attributed to the treatment in either guinea pigs or hamsters.