COMPARISON OF THE CARCINOGENIC EFFECTS OF 5 NITROSAMINES IN GUINEA-PIGS

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  • 1 January 1980
    • journal article
    • research article
    • Vol. 40  (6) , 1879-1884
Abstract
Five nitrosamines which are potent carcinogens were administered by gavage in olive oil solution twice a week to 20 male strain 2 guinea pigs. Nitroso-2,6-dimethylmorpholine given at 80 mg/kg per wk for 12 wk or at 32 mg/kg per wk for 35 wk gave rise to hemangioendothelial sarcomas of the liver in 6 and 19 animals, respectively. The same tumors were induced in 18 animals by dinitroso-2,6,dimethylpiperazine, together with hepatocellular carcinomas in 6 animals. Nitrosomethyldodecylamine also induced mainly hemangioendothelial sarcomas of the liver (12 animals). A few bile duct carcinomas were also observed. Neither nitrosoheptamethyleneimine nor nitrosomethyldiethylurea seemed to induce tumors in guinea pigs.