Alcohol-Induced Hepatic Injury in Nonalcoholic Volunteers

Publisher Website
Google Scholar
Abstract
Isocaloric substitution of alcohol for carbohydrate in young nonalcoholic volunteers rapidly led to hepatic fat accumulation and ultrastructural changes, both on a standard diet and on a diet high in protein and low in fat. The addition of alcohol to a normal diet for two days resulted in similar changes, which could not be prevented by a diet high in protein with minimal fat (5 per cent of total calories). Blood alcohol levels in every subject studied were almost all well below accepted legal limits for intoxication.