Effect of calcitonin on calcium concentration in serum and liver of rats ligated bile duct.

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Abstract
The s.c. administration of CT [calcitonin] (80 MRC mU[units]/100 g BW [body wt]) significantly prevented the increase of serum Ca concentration after a single oral injection of Ca (50 mg/100 g BW) to sham-operated rats. The ligation of bile duct prevented the hypocalcemic effect of CT. CT significantly increased the liver Ca content after the Ca injection to sham-operated rats. The liver Ca content after CT administration was markedly elevated by the ligation of bile duct in comparison with that of sham-operated rats. The liver Ca increased by CT administration secretes into the bile.

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