ACTIVATION AND SUPPRESSION OF T CELLS IN TERMINATION OF IMMUNOLOGICAL-TOLERANCE

  • 1 January 1976
    • journal article
    • research article
    • Vol. 31  (5) , 807-812
Abstract
Immunological tolerance was induced in adult C3H mice by 5 injections of ultra-centrifuged, soluble HSA [human serum albumin] at weekly intervals. The tolerant state was readily terminated by the challenge immunization with slightly sulfanilated HSA administered as Freund''s complete adjuvant emulsion. T [thymus-derived] cells specific for HSA were activated which could serve as helpers for the production of anti-hapten antibodies. The tolerance termination and activation of T cells specific for HSA was not observed in the profound tolerant state, induced by 9 injections of ultra-centrifuged, soluble HSA at weekly intervals, where suppressor T cells were detected. These results were discussed in reference to the development of autoimmunity.