Host Determinants of Response to Antimicrobial Agents

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Abstract
THE enthusiasm for definition of the etiology of an infection and for selection of the most effective antimicrobial agent often leads to inadequate consideration of the host, the battleground for the clash between the invading organism and the anti-infective compound. The emphasis is placed on the "bug" and the "drug," and little or no attention paid to what may be an important role of factors operating in the patient, other than those directly related to the infectious process, in conditioning the response to therapy. Although the infection itself determines to a great degree the kind of treatment to be employed, . . .