Prosomes discriminate between mRNA of adenovirus‐infected and uninfected HeLa cells
Open Access
- 27 March 1989
- journal article
- Published by Wiley in FEBS Letters
- Vol. 246 (1-2) , 131-136
- https://doi.org/10.1016/0014-5793(89)80268-6
Abstract
Prosomes are small cytoplasmic RNP complexes associated with repressed mRNA. In in vitro translation, they discriminate between the mRNA of adenovirus‐infected HeLa cells and those of uninfected cells grown under normal conditions. Prosomes as well as their RNA constituents interact much more strongly with poly(A)+ mRNA of infected cells and inhibit their translation in vitro preferentially. A possible role of prosomes in the differential regulation of translation is discussed.Keywords
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