Alpha-1-antitrypsin Pi S phenotype and liver cell inclusion bodies in alcoholic hepatitis.
Open Access
- 1 July 1979
- journal article
- research article
- Published by BMJ in Journal of Clinical Pathology
- Vol. 32 (7) , 706-709
- https://doi.org/10.1136/jcp.32.7.706
Abstract
Typical liver cell inclusions of alpha-1-antitrypsin deficiency were found in a patient with the Pi S phenotype and acute alcoholic hepatitis. It is suggested that the inclusions resulted from the combined effects of the S phenotype and alcohol and, on the basis of the known chemistry of the variant antitrypsins, that the lowered serum concentration of antitrypsin associated with the S allele may be due to hepatic holdup.This publication has 16 references indexed in Scilit:
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