SELECTIVE LOCALIZATION AND GROWTH OF BIFIDOBACTERIUM-BIFIDUM IN MOUSE-TUMORS FOLLOWING INTRAVENOUS ADMINISTRATION

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  • 1 January 1980
    • journal article
    • research article
    • Vol. 40  (6) , 2061-2068
Abstract
A strain of domestic bacteria, B. bifidum (Lac B), which is nonpathogenic and anaerobic, selectively localized and proliferated in several types of mouse tumors following i.v. administration. None of the same bacilli could be detected in the tissues of healthy organs such as the liver, spleen, kidney, lung, blood, bone marrow and muscle 48 or 96 h after i.v. administration into tumor-bearing mice. Proliferation of Lac B in the tumor was artificially stimulated by i.p. administration to DDD-H-2S mice of a synthesized disaccharide, lactulose (4-O-.beta.-D-galactopyranosyl-D-fructofuranose), a sugar which is not metabolized by mammalian tissue cells. Lac B, which survives and proliferates selectively in the tumor following i.v. administration into the tumor-bearing host, should aid in diagnosis and selective therapy for cancer.