C-19393 S2 and H2, new carbapenem antibiotics. I. Taxonomy of the producing strain, fermentation and antibacterial properties.

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Abstract
C-19393 S2 and H2 are new carbapenem antibiotics produced by a streptomycete. The producing strain was taxonomically studied and named Streptomyces griseus ssp. cryophilus. Cobaltous compounds were necessary for production of the antibiotics. C-19393 S2 and H2 showed a broad spectrum of antibacterial activities with C-19393 H2 being 8-120 times more active than C-19393 S2. They also exhibited .beta.-lactamase-inhibiting activities and acted synergistically with ampicillin and cefotiam against clinical isolates resistant to .beta.-lactam antibiotics.