Effects of Gal-E Mutant of Salmonella typhimurium on Experimental Salmonellosis in Chickens

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Abstract
Compared with unvaccinated challenged birds, day old chicks vaccinated orally with live S. typhimurium galactose epimerase mutant (G30D) and challenged orally after 14 days with a field strain of S. typhimurium had statistically significant reductions in fecal shedding (P < 0.01), in salmonella carrier status at slaughter (P < 0.05), in salmonella in the broiler-house environment (P < 0.005) and in serological response in the 4th wk after challenge (P < 0.005). The vaccine did not elicit a serological response as measured by plate, microagglutination and microantiglobulin tests. The vaccine had a significant depression on live-wt gain which was not apparent after 6 wk. The vaccine did not significantly reduce live wt at 8 wk below that of unvaccinated control birds. The field strain produced an 8% reduction in live wt at 8 wk below that of controls. The potential role of vaccines in Salmonella control and economic losses due to salmonellosis are discussed.