HLA—Cw4 in Paranoid Schizophrenia

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Abstract
Of 40 paranoid schizophrenic (SCH) patients HL-A serotyped for HL-A-A, B and C antigens, a significant increase of Cw4 was observed. This finding probably represents the common denominator for previous data reporting increased A9 and A28 antigens in SCH because these antigens are frequently present on haplotypes bearing Cw4. The possible role of HL-A central parts, i.e., the chromosomal segment between HL-A-A and HL-A-B locus in the pathogenesis of schizophrenia, was stressed.