SYNERGISM BETWEEN MINERALO- AND GLUCOCORTICOIDS IN THE PRODUCTION OF THE »PHOSPHATE-STEROID-CARDIOPATHY«

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Abstract
Experiments on rats indicate that a dose of 500 [mu]g daily of triamcinolone, ([DELTA] l-9[alpha]-fluoro-16-hydroxycortisol) a pure glucocorticoid, or administration of the pure mineralocorticoid, desoxycorticosterone, at a daily dose of 2.5 mg does not produce any significant degree of infarctoid cardiopathy in animals sensitized by the concurrent administration of large amounts of NaH2PO4. Combined treatment with small doses of both steroids produces extensive cardiac necroses. The author concludes that the concurrent effect of mineralo- and glucocorticoids is especially effective in conditioning the cardiac muscle for the necrotizing action of phosphate. This effect is particularly interesting since in so many other respects these two types of corticoids are antagonists in their action.