Uric Acid Transport System: Apparent Absence in Erythrocytes of the Dalmatian Coach Hound
- 21 August 1964
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 145 (3634) , 826-827
- https://doi.org/10.1126/science.145.3634.826
Abstract
The Dalmatian coach hound appears to lack a mediated transport system for uric acid, which can be demonstrated in the erythrocytes of other dogs by hypoxanthine inhibition of uric acid uptake. This transport deficiency may be a manifestation of a genetic defect which has different metabolic consequences in the liver, in the kidney, and in other tissues, depending on the direction of their differentiationKeywords
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