Calicheamicins, a novel family of antitumor antibiotics. Taxonomy, fermentation and biological properties.
- 1 January 1989
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 42 (4) , 558-563
- https://doi.org/10.7164/antibiotics.42.558
Abstract
A novel family of antitumor antibiotics, the calicheamicins, were isolated from the fermentation broth of Micromonospora echinospora subsp. calichensis. These antibiotics exhibited significant activity against Gram-positive and Gram-negative bacteria in vitro. Calicheamicin .gamma.1I demonstrated antitumor activity against P388 leukemia and B16 melanoma in vivo.This publication has 4 references indexed in Scilit:
- New antitumor antibiotics, FR-900405 and FR-900406. I. Taxonomy of the producing strain.The Journal of Antibiotics, 1985
- PD 114,759 and PD 115,028, novel antitumor antibiotics with phenomenal potency. I. Isolation and characterization.The Journal of Antibiotics, 1984
- BIOCHEMICAL PROPHAGE INDUCTION ASSAY - A RAPID TEST FOR ANTI-TUMOR AGENTS THAT INTERACT WITH DNA1983
- Some Bits and Pieces of the Genus Nocardia: N. carnea, N. vaccinii, N. transvalensis, N. orientalis and N. aerocolonigenesJournal of General Microbiology, 1978