Evidence for 15 genetically determined electrophoretic variants of transcobalamin II in rabbit serum

1 August 1979

journal article
research article
Published by Springer Nature in Biochemical Genetics

Vol. 17 (7-8) , 757-767
https://doi.org/10.1007/bf00502134

Abstract

By starch gel electrophoresis and autoradiography two classes of vitamin B₁₂ binding proteins were detected in rabbit serum. By analogy to the nomenclature used in man, the two classes of proteins were named “transcobalamin I” (TCI) and “transcobalamin II” (TCII). Fifteen TCII phenotypes were observed, and family data indicated that they are controlled by five allelic codominant genes. The possibility that the five genes arise from the action of at least two polymorphic and closely linked structural loci is discussed.

Keywords

This publication has 9 references indexed in Scilit:

Polymorphism of vitamin B12 [57Col binding proteins in rabbit serum
Animal Blood Groups and Biochemical Genetics, 2009
Detection of genetic variation with radioactive ligands. III. genetic polymorphism of transcobalamin II in human plasma.
1978
Group-specific component (Gc) proteins bind vitamin D and 25-hydroxyvitamin D.
Proceedings of the National Academy of Sciences, 1975
A Rapid Ammonium Sulfate Precipitation Technic for Separating Serum Vitamin B₁₂-binding Proteins: Method and Applications
American Journal of Clinical Pathology, 1974
Characterization of R‐Type Vitamin B₁₂‐Binding Proteins by Isoelectric Focusing
Scandinavian Journal of Haematology, 1974
An improved method for horizontal starch‐gel electrophoresis
Animal Blood Groups and Biochemical Genetics, 1970
Complexing of Transcobalamin 2 and Apparent Combination With Heparin
Blood, 1970