ON THE STRUCTURE OF GENE CONTROL REGIONS
Open Access
- 1 July 1974
- journal article
- research article
- Published by Oxford University Press (OUP) in Genetics
- Vol. 77 (3) , 541-558
- https://doi.org/10.1093/genetics/77.3.541
Abstract
A model emphasizing the possible genetic role of tandem duplications of reverse repeats has been developed as an extension of Crick's (1971) general model for the chromosomes of higher organisms. Although developed initially (1) to explain why random differences in the control regions of individual gene loci might confer a selective advantage on heterozygous individuals as well as (2) to offer the species a means by which such differences might be effected without mutational harm, it seems that control regions built on a foundation of tandemly duplicated reverse repeats would exhibit many properties previously observed in studies on mutable loci in various organisms.Keywords
This publication has 7 references indexed in Scilit:
- THE GENETIC CONTROL OF IMMUNOGLOBULIN SYNTHESISAnnual Review of Genetics, 1972
- Double-Stranded Regions in Heterogeneous Nuclear RNA from Hela CellsProceedings of the National Academy of Sciences, 1972
- Purification and Properties of Ribonuclease III from Escherichia coliJournal of Biological Chemistry, 1968
- A MOLECULAR APPROACH TO THE STUDY OF GENIC HETEROZYGOSITY IN NATURAL POPULATIONS. II. AMOUNT OF VARIATION AND DEGREE OF HETEROZYGOSITY IN NATURAL POPULATIONS OF DROSOPHILA PSEUDOOBSCURAGenetics, 1966
- An Analysis of Intragenic and Extragenic Mutations of the Plant Color Component of the Rr Gene Complex in Zea maysCold Spring Harbor Symposia on Quantitative Biology, 1958
- THE EFFECT OF HETEROZYGOSITY FOR NEW MUTATIONS ON VIABILITY IN Drosophila : A PRELIMINARY REPORTProceedings of the National Academy of Sciences, 1957
- THE STRUCTURE OF DNACold Spring Harbor Symposia on Quantitative Biology, 1953