α‐ADRENOCEPTOR BLOCKING DRUGS IN ASTHMA
Open Access
- 1 August 1976
- journal article
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 3 (4) , 601-605
- https://doi.org/10.1111/j.1365-2125.1976.tb04882.x
Abstract
1 The effect of α-adrenoceptor blocking drug, thymoxamine alone and in combination with isoprenaline, was studied on the specific airways conductance (SGaw) in ten patients with extrinsic asthma. 2 Thymoxamine when given together with isoprenaline produced significantly greater increase in SGaw as compared to improvement achieved with isoprenaline alone. 3 It is suggested that the potentiation of isoprenaline induced bronchodilatation by thymoxamine is mediated by increased cyclic AMP formation in the bronchial smooth muscle.Keywords
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