ITHE EFFECT OF CORTISONE IN EXPERIMENTAL HYPERVITAMINOSIS D1

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Abstract
Hypcrcalcemia is the recognized complication of overdosage with vitamin]) and cortisone is sometimes effective in reducing the concentration of serum calcium in this as well as other hypercalcemic states. The present experiment was designed to study the effect of cortisone in experimental hypervitaminosis D. Rats given 50,000 u. of vitamin D2 per kilo daily for 7 to 14 days developed hypercalcemia and metaphysial sclerosis. Larger doses (100,000 to 400,000 u.) promoted the formation of excess osteoid tissue and there was an accompanying increase in histological evidence of active bone resorption. In bones of rats given cortisone (50 mg./kg.) the metaphyses were dense and cartilage cell proliferation was reduced. However, concomitant administration of cortisone with vitamin D did not lessen the vitamin D induced hypercalcemia, and bones from these rats showed combined effects of both compounds. These results suggest that in rats cortisone and vitamin D act independently rather than competitively on bon