Immune-mediated Loss of Transgene Expression From Virally Transduced Brain Cells Is Irreversible, Mediated by IFNγ, Perforin, and TNFα, and due to the Elimination of Transduced Cells

This publication has 54 references indexed in Scilit:

• Recovery from viral encephalomyelitis: immune-mediated noncytolytic virus clearance from neurons
  Immunologic Research, 2010
• Gene Transfer into Rat Brain Using Adenoviral Vectors
  Current Protocols in Neuroscience, 2010
• Herpes simplex type I (HSV-1) infection of the nervous system: Is an immune response a good thing?
  Journal of Neuroimmunology, 2009
• Gene- and Viral-Based Therapies for Brain Tumors
  Neurotherapeutics, 2009
• Gene Transfer into Neural Cells In Vitro Using Adenoviral Vectors
  Current Protocols in Neuroscience, 2008
• One-year Expression From High-capacity Adenoviral Vectors in the Brains of Animals With Pre-existing Anti-adenoviral Immunity: Clinical Implications
  Molecular Therapy, 2007
• Existence of transient functional double-stranded DNA intermediates during recombinant AAV transduction
  Proceedings of the National Academy of Sciences, 2007
• Effects of transient immunosuppression on adenoassociated, virus-mediated, liver-directed gene transfer in rhesus macaques and implications for human gene therapy
  Blood, 2006
• Immunological thresholds in neurological gene therapy: highly efficient elimination of transduced cells might be related to the specific formation of immunological synapses between T cells and virus-infected brain cells
  Neuron Glia Biology, 2006
• In vivo mature immunological synapses forming SMACs mediate clearance of virally infected astrocytes from the brain
  The Journal of Experimental Medicine, 2006