Comparison of two calcium antagonists, verapamil and fendiline, in an experimental model of myocardial ischaemia mimicking classical angina on effort

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Abstract
The effects of verapamil (0.15/kg) and fendiline (3 mg/kg) were studied in anesthetized, thoracotomized dogs with a critical constriction of the left anterior descending coronary artery, paced in excess of the initial rate by 60-70 beats/min. Epicardial ST-segment elevation and changes in lactate uptake were used to assess the severity of myocardial ischemia. Both drugs prevented the ST-segment elevation and the reduced lactate uptake that resulted from atrial pacing. The anti-ischemic effect of fendiline is mainly due to its negative chronotropic action, whereas that of verapamil is due in part to the reduced preload and afterload. Both agents increase coronary flow to the ischemic area and improve the myocardial O2 supply/O2 requirement ratio.

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