Fungal detoxication. 2. The metabolism of some phenoxy-n-alkylcarboxylic acids by Aspergillus niger

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Abstract
By the use of a replacement culture technique it was demonstrated that phenoxyacetic and [beta]-phenoxypropionic acids were hydroxylated in the para, and to a lesser extent the ortho, positions by A. niger, both products in each case being less toxic to the fungus than the original acid. Gamma-phenoxy-n-butyric acid likewise gave mainly p-hydroxy-phenoxyacetic acid by hydroxylation and [beta]-oxidation. [delta]-Phenoxy-n-valeric acid was similarly metabolized to [beta]-(p-hydroxyphenoxy) propionic acid (and probably also to the o-hydroxy acid).