Regulation of B-cell proliferative responses to lipopolysaccharide by a subclass of thymus T cells.

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Abstract
When thymus cells [mouse] which are unresponsive to LPS [lipopolysaccharide] are combined with numbers of peripheral lymphoid cells giving minimal responses to LPS, synergistic incorporation of [3H]thymidine occurs. Synergy requires that both components proliferate, but most of the augmented response is the result of peripheral cell proliferation. The thymus cell is a T [thymus derived] cell of variable density, low in Thy-1.2 antigen, not concanavalin A responsive, present in the major thymus subpopulation and may be from LPS-unresponsive strains. The peripheral cell is sensitive to anti-Ig[immunoglobulin]G or IgM plus complement (C), resistant to anti-Thy-1.2 and C, exhibits adherence properties of B [bone marrow derived] lymphocytes and must be from LPS-responsive strains. Synergistic responses depend on critical thymus/peripheral cell ratios, inhibition occurring at high peripheral cell numbers. B-cell proliferative responses to LPS may be regulated by a subclass of thymus T cells.
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