HYPERACTIVE T-CELL FUNCTION IN YOUNG NZB MICE - INCREASED PROLIFERATIVE RESPONSES TO ALLOGENIC CELLS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 23  (3) , 578-581
Abstract
The 1 way mixed lymphocyte reaction was employed to study proliferative responses to antigens by mature, immunocompetent T [thymus-derived] cells from NZB mice 3 wk-4 mo. old. Compared to cells from control mice of the same H-2 type, thymus, spleen and lymph node cells from NZB mice were hyperactive in this response. The results are discussed in relation to possible effects of chronic stimulation by endogenous type C leukemia virus upon differentiation of functional T cells or upon regulation by T cells of other T-cell functions, including augmentation of antibody responses.

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