The Effect of Splenectomy on the Production of Anaphylactic Shock in the Guinea Pig and the Rat

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Abstract
Splenectomy in the guinea pig affords protection against active anaphylactic shock, if the operation is performed a short time before the challenge with antigen. When the challenge is made under ether anaesthesia, the maximal protective action is present 24 hours after splenectomy but is lost during the next 48 hours. If the challenge is made under urethane anaesthesia, the protective action is present 72 hours after the operation. The mechanism of the protective action of splenectomy is not clear, although it may be due to a loss of tissue antibodies or of complement since passive anaphylaxis is not altered by the operation. In contrast, removal of the spleen in the rat fails to modify the symptoms of anaphylactic shock.

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