The immunological response of CBA mice to Trypanosoma musculi. I. Initial control of the infection and the effect of T-cell deprivation.

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  • 1 February 1974
    • journal article
    • Vol. 16  (2) , 279-94
Abstract
Trypanosoma musculi produced a self-limiting infection in CBA mice which was characterized by a phase of increasing parasitaemia, during which dividing forms of the parasite were present in the blood, and a more stable plateau phase, when only non-dividing `adult' parasites are seen. Blood parasitaemia then rapidly regressed and subsequently blood was non-infective on sub-inoculation. Infection of normal mice in this manner apparently conferred a strong and lasting immunity. Fluorescent antibody titres rose rapidly during infection and IgM, IgGl and IgG2 antibodies were synthesized simultaneously. Total immunoglobulin and IgG2 antibody titres fell following recovery from infection but relatively high and constant antibody levels were detectable for many months.