Connected to Death: The (Unexpurgated) Mitochondrial Pathway of Apoptosis
- 7 October 2005
- journal article
- special viewpoints
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 310 (5745) , 66-67
- https://doi.org/10.1126/science.1117105
Abstract
The mitochondrial pathway of apoptosis in vertebrates is dependent on the process of mitochondrial outer membrane permeabilization (MOMP), which leads to the release of proteins from the mitochondrial intermembrane space into the cytosol. “Upstairs” of this event are the Bcl-2 family proteins that regulate and mediate MOMP; “downstairs” is the activation of caspases that orchestrate the dismantling of the cell. In the Connections Map database at Science's Signal Transduction Knowledge Environment (STKE), the pathways that define the mitochondrial pathway of apotosis are illustrated, with the bulk of control occurring “upstairs” of MOMP.Keywords
This publication has 4 references indexed in Scilit:
- Do inducers of apoptosis trigger caspase-independent cell death?Nature Reviews Molecular Cell Biology, 2005
- Cell Death: Critical Control PointsPublished by Elsevier ,2004
- Mechanisms of caspase activationPublished by Elsevier ,2003
- A matter of life and deathCancer Cell, 2002