THE RATE OF EXCRETION OF HEPARIN IN THE URINE FOLLOWING ITS INTRAVENOUS INJECTION IN THE ANESTHETIZED DOG

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Abstract
Heparin is excreted in the urine of dogs anesthetized with Na pentobarbital following the intraven. inj. of heparin in doses of 200 U per kg of body wt.. The presence of heparin in the urine was indicated by the metachromatic reaction with toluidine blue and a prolonged coagulation time by the addition of normal blood to the urine. The amt. of heparin excreted by the kidneys was detd. by the toluidine blue method. The excretion of heparin reached its highest level within 20 to 50 min. after its inj. A total of 9.9 to 35.6% of the injected heparin was excreted in the urine within 110 min. The disappearance of heparin from the urine is associated with a return toward normal of the coagulation time of the blood of the heparinized dog.

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