Membrane Alterations in Hemolysis: Internalization of Plasmalemma Induced by Primaquine
- 16 May 1969
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 164 (3881) , 843-845
- https://doi.org/10.1126/science.164.3881.843
Abstract
Incubation of normal human erythrocytes with primaquine, a derivative of 8-aminoquinoline, results in internalization of the cell membrane and the formation of intracellular vacuoles. These changes are similar to those observed in other types of cells in pinocytosis. The reduction in surface cell membrane which accompanies internalization of plasmalemma may be generally significant in the destruction of red cells.Keywords
This publication has 9 references indexed in Scilit:
- The conformational basis of energy transformations in membrane systemsArchives of Biochemistry and Biophysics, 1968
- The effect of primaquine on lecithin metabolism in human erythrocytesBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1966
- Membrane alterations leading to red cell destructionThe American Journal of Medicine, 1966
- Studies of in vitro primaquine hemolysis: substrate requirement for erythrocyte membrane damage.Journal of Clinical Investigation, 1966
- Generation of Hydrogen Peroxide in Erythrocytes by Hemolytic Agents*Biochemistry, 1964
- Glutathione Peroxidase: The Primary Agent for the Elimination of Hydrogen Peroxide in Erythrocytes*Biochemistry, 1963
- STUDIES ON THE MODE OF ACTION OF EXCESS OF VITAMIN AThe Journal of cell biology, 1963
- Glucose-6-Phosphate Dehydrogenase and Detoxification of Hydrogen Peroxide in Human ErythrocytesScience, 1961
- EFFECTS OF PRIMAQUINE AND OTHER RELATED COMPOUNDS ON THE RED BLOOD CELL MEMBRANE. I. NA+ AND K+ PERMEABILITY IN NORMAL HUMAN CELLS*Journal of Clinical Investigation, 1961