EFFECT OF DIET ON GLUCOSE TOLERANCE AND LIVER AND MUSCLE GLYCOGEN OF HYPOPHYSECTOMIZED AND NORMAL RATS1,2

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Abstract
Hypophysectomized rats fed adequate amts. of diets in which 85 to 90% of the calories were supplied by either carbohydrate or fat were given glucose tolerance tests after a 24-hr. fasting period. Both showed the delayed removal during the glycogenic period, but the fat-fed rats were better able to maintain their blood-sugar levels during the period of glycogenolysis. Some were not able to maintain the blood-sugar level as well as the normal animals, however. The greater ability to maintain the blood-sugar levels was associated with better liver and muscle glycogen supplies at the end of the expt. This is additional evidence that the metabolic disturbance in hypophysectomized rats is not in ability to use any one of the foodstuffs so long as it is available in proper form in the liver and circulation. The fundamental disturbance is in the mobilization of endogenous stores, both of protein and fat. Adjustment of either a normal or hypophysectomized rat to a high fat diet before fasting increased the relative rate of utilization of fat and decreased carbohydrate utilization during a subsequent fasting period.

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