Submitochondrial localization of rat liver .BETA.-alanine-oxoglutarate aminotransferase.

Open Access
Publisher Website
Google Scholar
Abstract
β-Alanine-oxoglutarate aminotransferase from rat liver was mainly distributed in the mitochondrial fraction, while β-ureidopropionase, the last one of uracil-metabolizing enzymes to β-alanine, was predominantly distributed in the cytosolic fraction. When rat liver mitochondria were separated into submitochondrial fractions, β-alanineoxoglutarate aminotransferase was localized in the mitochondrial matrix. β-Alanine was transported into mitochondria with time and the influx of β-alanine into the matrix was 0.47 nmol/mg of mitochondrial protein at 2 min after incubation.