A LABORATORY STUDY OF THE CARRIER STATE IN CLASSIC HEMOPHILIA 1

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Abstract
From the sociologic and medical points of view it would be important to detect those females who are conductors of the genetic defect responsible for hemophilia. Nineteen presumptive and 8 possible carriers of classic hemophilia were tested for possible evidences of a defect in their coagulation mechanisms. A definitely reduced concentration of anti-hemophilic factor was demonstrated in only one carrier, although minor abnormalities were found in several others. Thus it was not possible to detect the carrier state in the great majority of carriers. The implications of these observations are discussed.