Prolonged Immunosuppression and Tumor Induction by a Chemical Carcinogen Injected at Birth
- 29 April 1966
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 152 (3722) , 650-651
- https://doi.org/10.1126/science.152.3722.650
Abstract
The injection of 60 micrograms of 9,10-dimethyl-1,2-benzanthracene into newborn mice gave rise to a very high incidence of malignant thymomas. The tumor incidence was directly related to the dose of the carcinogen. The neonatal injection of the carcinogen also resulted in a depression in the immune response when the animals were challenged with an antigen as early as 4 weeks or as late as 11 weeks after administration of the carcinogen.This publication has 10 references indexed in Scilit:
- Time-course Studies on Antibody Response in Thymectomized and Sham-thymectomized MiceNature, 1965
- Immunodepressive Effect of 3-Methylcholanthrene. Antibody Formation at the Cellular Level and Reaction Against Weak Antigenic Homografts2JNCI Journal of the National Cancer Institute, 1965
- Studies on Mouse AntibodiesThe Journal of Immunology, 1965
- STUDIES ON MOUSE ANTIBODIES .I. RESPONSE TO SHEEP RED CELLS1965
- EFFECTS OF CARCINOGENS ON IMMUNE PROCESSESBritish Medical Bulletin, 1964
- On the Statistical Distribution of Epidermal Papillomata in MiceBritish Journal of Cancer, 1964
- Response of Newly Born Mice to a Chemical CarcinogenNature, 1959
- Immunity to Methylcholanthrene-Induced SarcomasJNCI Journal of the National Cancer Institute, 1957
- Reduced Antibody Titers in Mice Treated with Carcinogenic and Cancer Chemotherapeutic AgentsExperimental Biology and Medicine, 1952
- The Effect of Splenectomy on the Formation of Circulating Antibody in the Adult Male Albino RatThe Journal of Immunology, 1950