The effect of nisin on murein synthesis

1 October 1980

journal article
research article
Published by Springer Nature in Archiv für Mikrobiologie

Vol. 127 (3) , 187-193
https://doi.org/10.1007/bf00427192

Abstract

Nisin inhibits murein synthesis with concomitant accumulation of undecaprenyl-pyrophospho-MurNAc(pentapeptide) (lipid intermediate I). This inhibition is caused by the formation of a complex between the antibiotic and lipid intermediate I. Undecaprenyl-pyrophospho-MurNAc(pentapeptide)-GlcNAc (lipid intermediate II) also forms a complex with nisin. However, when murein synthesis is inhibited by nisin, this latter complex is not formed since lipid intermediate II is no longer synthesized.

Keywords

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