Additional Antibiotic Inhibitors of Peptidoglycan Synthesis
Open Access
- 1 September 1973
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 4 (3) , 231-236
- https://doi.org/10.1128/aac.4.3.231
Abstract
Diumycin, janiemycin, nisin, and subtilin inhibited peptidoglycan synthesis catalyzed by particulate enzyme systems from Bacillus stearothermophilus and Escherichia coli . All of these, except for nisin, also induced accumulation of the lipid intermediate in peptidoglycan synthesis. Concentrations required for 50% inhibition of peptidoglycan synthesis were less than 0.1 μg/ml for diumycin and in the range of 10 to 100 μg/ml for janiemycin, nisin, and subtilin in both organisms. The discrepancy between the extremely low concentration of diumycin required to inhibit the in vitro system from E. coli and the much higher concentration required to inhibit growth of the organism is noteworthy.Keywords
This publication has 28 references indexed in Scilit:
- Inhibition of Peptidoglycan Synthesis by the Antibiotic Diumycin AAntimicrobial Agents and Chemotherapy, 1972
- BIOLOGICAL CHARACTERIZATION OF DIUMYCIN, A PHOSPHORUS-CONTAINING GLYCOLIPID ANTIBIOTICThe Journal of Antibiotics, 1972
- Structure of nisinJournal of the American Chemical Society, 1971
- Structure of a novel lipid from the antibiotic diumycinJournal of the American Chemical Society, 1970
- JANIEMYCIN, A NEW PEPTIDE ANTIBIOTICThe Journal of Antibiotics, 1970
- Molecular Association of the Antibiotic PrasinomycinsJournal of Pharmaceutical Sciences, 1968
- Moenomycin, V1) Strukturaufklärung des Lipoid-Teils von Moenomycin2)European Journal of Organic Chemistry, 1968
- Moenomycin, an inhibitor of cell wall synthesisBiochemical and Biophysical Research Communications, 1968
- The Prasinomycins: Antibiotics containing PhosphorusNature, 1967
- Enzymatic synthesis of cell wall mucopeptide in a particulate preparation of Escherichia coliBiochemical and Biophysical Research Communications, 1966