MACROPHAGE ACTIVATION BY MDP BOUND TO NEOGLYCOPROTEINS - METASTASIS ERADICATION IN MICE
- 1 January 1985
- journal article
- research article
- Vol. 5 (4) , 218-232
Abstract
Neoglycoproteins, which bind to membrane lectins of macrophages and are selectively endocytosed, were substituted with N-acetymuramyldipeptide (MDP). Such MDP-conjugates are shown to be able to induce macrophage tumoricity both in vitro and in vivo in a way much more efficient than free MDP does. These MDP-neoglycoprotein conjugates are shown to protect mice against metastatic growth.This publication has 13 references indexed in Scilit:
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