Mechanisms of in vitro immunosuppression by hepatocyte-generated cyclophosphamide metabolites and 4-hydroperoxycyclophosphamide
- 1 September 1990
- journal article
- research article
- Published by Elsevier in Biochemical Pharmacology
- Vol. 40 (5) , 927-935
- https://doi.org/10.1016/0006-2952(90)90476-2
Abstract
No abstract availableThis publication has 27 references indexed in Scilit:
- In vitro/in vivo effects of Mesna on the genotoxicity and toxicity of cyclophosphamide — a study aimed at clarifying the mechanism of Mesna's anticarcinogenic activityToxicology Letters, 1988
- Enhancement of the embryotoxicity of acrolein, but not phosphoramide mustard, by glutathione depletion in rat embryos in vitroBiochemical Pharmacology, 1987
- Influence of mesna and cysteine on the systemic toxicity and therapeutic efficacy of activated cyclophosphamideZeitschrift für Krebsforschung und Klinische Onkologie, 1987
- Immunosuppression induced by chemicals requiring metabolic activation in mixed cultures of rat hepatocytes and murine splenocytesToxicology and Applied Pharmacology, 1986
- Does 2‐mercaptoethane sulphonate (mesna) prevent cyclophosphamide and azathioprine induced immunosuppression? In vitro studies.British Journal of Clinical Pharmacology, 1986
- Does acrolein contribute to the cytotoxicity of cyclophosphamide?Zeitschrift für Krebsforschung und Klinische Onkologie, 1980
- Cyclophosphamide cystitis—Identification of acrolein as the causative agentBiochemical Pharmacology, 1979
- Studies on the binding of [3H-chloroethyl]-cyclophosphamide and 14[C-4]-cyclophosphamide to hepatic microsomes and native calf thymus DNALife Sciences, 1978
- Effect of n-acetylcysteine on some aspects of cyclophosphamide-induced toxicity and immunosuppressionBiochemical Pharmacology, 1977
- Some studies of the active intermediates formed in the microsomal metabolism of cyclophosphamide and isophosphamideBiochemical Pharmacology, 1974