Plasma Cortisol Response to Thyrotropin-Releasing Hormone and Luteinizing Hormone-Releasing Hormone in Cushing's Disease
- 1 May 1979
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 48 (5) , 874-876
- https://doi.org/10.1210/jcem-48-5-874
Abstract
In 3 of 6 patients with pituitary-dependent Cushing's disease, a paradoxical increase of plasma cortisol was observed both after LRH (δmax, 13.9 ± 3.7 μg/100 ml; 113 ± 52%) and TRH (δmax, 8.0 ± 2.9 μg/100 ml; 53 ± 18%) administration, the maximum values being achieved 30–60 min after the iv bolus injection. In the remaining 3 patients and in 15 control subjects, plasma cortisol levels did not rise in response to either LRH or TRH administration but rather showed a slight to distinct decrease during the study period. The paradoxical cortisol response in half of the patients with Cushing's disease may be the consequence of loss of specificity of the pituitary receptor or alteration in the hypothalamo-pituitary pathways.Keywords
This publication has 5 references indexed in Scilit:
- THE EFFECT OF CYPROTERONE ACETATE ON THE PITUITARY-ADRENAL AXIS IN HIRSUTE WOMENActa Endocrinologica, 1978
- CYPROHEPTADINE TREATMENT OF NELSON′S SYNDROME: RESTORATION OF PLASMA ACTH CIRCADIAN PERIODICITY AND REVERSAL OF RESPONSE TO TRF1,2Journal of Clinical Endocrinology & Metabolism, 1978
- Adenylate Cyclase of GH and ACTH Producing Tumors of Human: Activation by Non-specific Hormones and Other Bioactive SubstancesJournal of Clinical Endocrinology & Metabolism, 1977
- Plasma ACTH and Cortisol Responses to TRF, Vasopressin or Hypoglycemia in Cushing's Disease and Nelson′s SyndromeJournal of Clinical Endocrinology & Metabolism, 1977
- PITUITARY HORMONE RESPONSES TO HYPOTHALAMIC RELEASING HORMONES IN ACROMEGALYActa Endocrinologica, 1976