The effect of synthetic double-stranded polyribonucleotides on haemopoietic colony-forming cells in vitro.

Google Scholar
  • 1 November 1971
    • journal article
    • Vol. 21  (5) , 741-50
Abstract
Addition of low concentrations of the synthetic double-stranded polynucleotides Poly I—Poly C and Poly AU to stimulated cultures of normal mouse bone marrow increased the number of macrophage colonies in the cultures. Double strandedness of the polynucleotides was essential for activity and they were active without the α-globulin which was previously shown to be a necessary co-factor in colony potentiation by some antigens. The evidence suggested that polynucleotides acted at the cell surface to make colony forming cells more responsive to colony stimulating factor.