Antigenic stimulation of bone marrow colony forming cells. 3. Effect in vivo.

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  • 1 January 1970
    • journal article
    • Vol. 18  (1) , 61-72
Abstract
It has been shown that intraperitoneal injection of Freund's complete adjuvant can stimulate the multiplication and effect the distribution within the animal of cells which form granulocytic and monocytic colonies in vitro. This response is associated with a leukocytosis and a fall in haematocrit. A variety of antigens were tested all of which resulted in an increase in the number of colony forming cells in the spleen to a greater or lesser degree. Two mechanisms are thought to be involved in this response: (1) with some antigens a direct stimulation of colony forming cells by an antigen—α-macroglobulin complex; and (2) an indirect stimulation of colony forming cells by release of colony stimulating factor from cells other than the colony forming cells.