Experimental Eosinophilia X. Relation of Antigen-Antibody Complex Size and Protein Molecular Weight to Cell Responses.

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Abstract
Specific proteins and their corresponding antigen-antibody complexes of varying molecular sizes and physico-chemical character were studied for their properties of inducing inflammatory cell infiltrations into regional lymph nodes after cutaneous injection. Eosinophil responses were quantitated in guinea pig models effected by bovine ribonuclease (BRN), serum albumin (BSA), gamma globulin (BGG), thyroglobulin (BTG), horse spleen ferritin (HSF), lobster hemocyanin (HCN), and tobacco mosaic virus (TMV) systems. The smaller size immune complexes and lower molecular weight pro-teins evoked significantly greater eosinophilia (BRN>BSA, BGG, HSF > BTG, HCN, TMV) when given in equal weight dosages. Sig-nificant differences were not found with equimolar preparations. Numbers rather than size of presenting antigen-antibody complexes or protein molecular aggregates were a critical factor in the degree of emerging inflammatory eosinophil cell response.