RELATION BETWEEN MOLECULAR WEIGHT OF ANTIGEN AND ABILITY TO ELICIT PASSIVE CUTANEOUS ANAPHYLAXIS

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  • 1 January 1962
    • journal article
    • research article
    • Vol. 5  (1) , 1-+
Abstract
Passive cutaneous anaphylaxis in the guinea pig has been studied with rabbit antibody to a series of antigens of differing molecular weight. The results indicated that at a given antibody level the weight of antigen needed to elicit a reaction increases with its molecular weight. Previous observations have been confirmed that the amount of antigen needed to elicit a reaction at a high level of antibody is less than that required at a lower level. The results suggest that extremely small amounts of small molecular weight antigens might be sufficient to produce anaphylactic symptoms in highly sensitive individuals.