HLA-A2-Restricted CD8+-Cytotoxic-T-Cell Responses to Novel Epitopes inMycobacterium tuberculosisSuperoxide Dismutase, Alanine Dehydrogenase, and Glutamine Synthetase
Open Access
- 1 April 2004
- journal article
- research article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 72 (4) , 2412-2415
- https://doi.org/10.1128/iai.72.4.2412-2415.2004
Abstract
Major histocompatibility complex class I-restricted CD8+ cytotoxic T lymphocytes (CTL) are implicated in protective Th1 immunity to Mycobacterium tuberculosis infection. We report the identification of three novel HLA-A*0201-restricted CTL epitopes within mycobacterial superoxide dismutase (SodA), l-alanine dehydrogenase (AlaDH), and l-glutamine synthetase (GlnS) proteins.Keywords
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