COMPARISON OF NICOTINAMIDE ADENINE DINUCLEOTIDE SYNTHESIS BY MYCOBACTERIUM TUBERCULOSIS AND MYCOBACTERIUM BOVIS
- 1 December 1966
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Microbiology
- Vol. 12 (6) , 1225-1233
- https://doi.org/10.1139/m66-164
Abstract
The R1Rvstrain of M. tuberculosis utilized nicotinic acid for the synthesis of nicotinamide adenine dinucleotide (NAD). Nicotinic acid mononucleotide (NaMN) and nicotinic acid dinucleotide (NaAD) were identified among the enzymatic reaction mixture products. A comparison with M. bovis demonstrated a greater capacity for NAD synthesis by the bovine bacillus. It has been hypothesized that reduced NAD synthesis and failure to utilize intermediates which continue to be produced are responsible for the excessive nicotinic acid accumulation by M. tuberculosis.This publication has 14 references indexed in Scilit:
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