Angiotensin blood levels in hypovolemic shock during osmotic diuresis

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Abstract
Angiotensin blood levels were determined by the Scornik-Paladini method in anesthetized dogs with hemorrhagic shock and were significantly higher than in the control period. The infusion of hyper-tonic glucose and mannitol solutions impaired this response. Hyper-tonic NaCl solution did so only if a mercurial diuretic was given simultaneously. Renal vein blood of receptor kidneys perfused by a nephrectomized donor dog showed an increased angiotension level when the perfusion pressure was reduced to 40 mm Hg. This rise was also decreased by the infusion of hypertonic glucose solution. Neither the hypertonic solutions used nor the addition of a mercurial diuretic to the NaCl solution modified angiotensin blood levels in the anesthetized normotensive dogs. These findings contradict the baro-receptor theory of renin secretion and support the receptor role of the macula densa. Ureteral ligature and controlled increased ureteral pressure did not modify the rise in angiotensin blood level caused by hemorrhagic shock. Hence, the stimulus at the macula densa is probably of a chemical, osmotic nature, rather than mechanical.

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