Quantitative studies on the Rh‐antigen D
- 5 May 1987
- journal article
- research article
- Published by Wiley in Transfusion
- Vol. 27 (3) , 257-261
- https://doi.org/10.1046/j.1537-2995.1987.27387235634.x
Abstract
Using an automated antiglobulin consumption test and Scatchard''s anaysis, the authors measured the number of D antigen epitopes on each of 46 samples of washed red cells (RBC) that represented six different Rh phenotypes. A clear D dosage effect was observed only when C was missing from the Rh genome, which confirmed the previously recognized suppressive effect of C. Thus, RBC of the Rh phenotype R2R2 had almost twice as many D epitopes (mean, 30,300/cell) as RBC of the Rh phenotypes R2r and Ror (means, 17,200 and 16,500 respectively). The data indicated that C in trans and cis suppressed similar amounts of D epitopes.This publication has 19 references indexed in Scilit:
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